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Medical Cannabis for Depressive and Anxiety Disorders

The impact of a workplace of motor vehicle accident can be long-lasting and go beyond physical injury.  It is quite normal to develop anxiety, panic disorders and/or depression as the body tries to manage the physical and emotional toll of trauma to the body and mind.

Medical Cannabis for Depressive and Anxiety Disorders

Cannabidiol, (CBD), is one of the principal non psycho-active compounds in medical cannabis and has demonstrated both antidepressant and anti-anxiety effects in animal models (de Mello Schier, et al., 2014) and (Zanelati, et al., 2010). Tetrahydrocannabinol (THC), the main psycho-active compound in cannabis has also been shown to decrease brain activity in response to negative stimuli (but not positive stimuli) (Bossong, et al., 2013). Cannabichromene (CBC), another compound found in cannabis, has shown to provide significant antidepressant-like effects when administered on its own, as well as when combined with THC (El-Alfy, et al., 2010). In addition, CBC has shown to encourage central neurogenesis, in turn helping prevent the decline of growth in these cells, which is thought to contribute to disorders like depression (Shinjyo & Di Marzo, 2013).  For anxiety symptoms, CBD has effects on the limbic and paralimbic areas of the brain.  The stimulation of these areas is thought to be responsible for the anxiolytic properties of CBD/THC combination and this combination has shown to significantly decrease subjective anxiety (Crippa, et al., 2011).  Moreover, it is reported that the oral use of CBD significantly reduces the anxiety, cognitive impairment and discomfort associated with public speaking in individuals with Generalized Social Anxiety Disorder (SAD) (Bergamaschi, et al., 2011). The use of CBC can also reduce anxiety and stress levels. Cannabinoids, like CBC, interact with CB1 receptors of the endocannabinoid system, which in turn stimulate the release of GABBA that reduce the excitability of brain cells (Ramikie, et al, 2014).

If the depressive or anxious disorder is associated with insomnia or sleep dysregulation, the psychoactive compound Cannabinol (CBN) can also be useful.  Of all the cannabinoids, CBN is the most sedative, making it a potential therapeutic option for those with insomnia, sleep apnea or other sleep disorders. CBN and its derivatives have shown effective at significantly prolonging sleeping time in mice (Yoshida, et al., 1995), (Usami, et al., 1998) and (Takahashi & Karniol, 1975).   Research suggests that sleeping improvements are even greater when CBN is combined with THC (Karniol, et al., 1975).

If you or a loved one has suffered an accident or personal trauma and would like more information on accessing safe, effective cannabis to treat depression and/or anxiety, contact Medical Marijuana Group (MMG) by clicking here

By | 2017-01-25T16:25:11-05:00 January 24th, 2017|Blog, Medical Marijuana|4,494 Comments

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